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The initial outcome of the mitochondrial respiratory chain is the generation of O 2 , which is formed at numerous mitochondrial locations, encompassing NADH:ubiquinone oxidoreductase (complex I), succinate dehydrogenase (complex II), ubiquinol:cytochrome c oxidoreductase (complex III), and mitochondrial glycerol 3-phosphate dehydrogenase [15]

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Alcohol and tobacco use Both cigarette smoking and excessive alcohol use have been linked to disruptions in menstrual cycles

Systemic oxidative stress in asthma, COPD, and smokers

It has been associated with oxidative DNA damage in conditions such as aging, cancer and pro-oxidant environmental exposures